Astrocytes: Orchestrating synaptic plasticity?
نویسندگان
چکیده
منابع مشابه
Astrocytes: Orchestrating synaptic plasticity?
Synaptic plasticity is the capacity of a preexisting connection between two neurons to change in strength as a function of neural activity. Because synaptic plasticity is the major candidate mechanism for learning and memory, the elucidation of its constituting mechanisms is of crucial importance in many aspects of normal and pathological brain function. In particular, a prominent aspect that r...
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In the brain, astrocytes dynamically interact with neuronal synapses via fine processes. New data show that, in response to synaptic plasticity stimuli, astrocyte processes rapidly move towards and enwrap active synapses, aiding in the stabilization and maintenance of active connections.
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Recently, Henneberger and colleagues blocked hippocampal long-term synaptic potentiation (LTP) induction by "clamping" intracellular calcium concentration of individual CA1 astrocytes, suggesting calcium-dependent gliotransmitter release from astocytes plays a role in hippocampal LTP induction. However, using transgenic mice to manipulate astrocytic calcium, Agulhon and colleagues demonstrated ...
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Recently, Henneberger and colleagues blocked hippocampal longterm synaptic potentiation (LTP) induction by “clamping” intracellular calcium concentration of individual CA1 astrocytes, suggesting calcium-dependent gliotransmitter release from astocytes plays a role in hippocampal LTP induction. However, using transgenic mice to manipulate astrocytic calcium, Agulhon and colleagues demonstrated n...
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Astrocytes, via excitatory amino-acid transporter type-2 (EAAT2), are the major sink for released glutamate and contribute to set the strength and timing of synaptic inputs. The conditions required for the emergence of Hebbian plasticity from distributed neural activity remain elusive. Here, we investigate the role of EAAT2 in the expression of a major physiologically relevant form of Hebbian l...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2016
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2015.04.001